Exposure to cobalt metal (without tungsten carbide) and some cobalt compounds: a literature review

Authors

  • Amélia Paula Marinho Reis Earth Sciences Department, University of Minho

DOI:

https://doi.org/10.21814/jus.5230

Keywords:

exposure pathways, human health, dietary intake, environment, industry.

Abstract

Cobalt is a natural metallic element with extensive applications across multiple industries, and a critical metal for lithium-ion battery production. Cobalt's only known biological function is its role as a metal component of vitamin B12. Other cobalt compounds have been described as toxic to the environment and the human body following excessive exposure. The International Agency for Research on Cancer (IARC) has classified cobalt, including cobalt metal and soluble cobalt(II) salts, as Group 2A, meaning it is probably carcinogenic to humans. This review aims to present a comprehensive overview of historical and current sources of cobalt in diverse exposure settings, along with its various intake routes. An extensive literature search was conducted between September 2021 and January 2022, analysing over 300 publications. The primary goal of these studies was to identify cobalt sources, intake routes, and exposure pathways. Workers may be exposed to various cobalt compounds and metal powders primarily through inhalation, but exposure can also occur via skin contact or ingestion. For the general population, food typically arises as the predominant source of cobalt exposure. Furthermore, exposure may occur through ambient air, tobacco smoke, and medical implants.

References

IARC - International Agency for Research on Cancer, Cobalt, antimony compounds, and weapons-grade tungsten alloy. IARC Monogr Identif Carcinog Hazards Hum., The International Agency for Research on Cancer, World Health Organization, vol. 131. ISBN 9789283201984 (ebook).

L. Leyssens, B. Vinck, C. Van Der Straeten, F. Wuyts and L. Maes. “Cobalt toxicity in humans-A review of the potential sources and systemic health effects.” Toxicology. Vol. 387, Jul., pp. 43-56, 2017. doi: 10.1016/j.tox.2017.05.015. DOI: https://doi.org/10.1016/j.tox.2017.05.015

M.R. Karagas, A. Wang, D.C. Dorman, A.L. Hall, J. Pi, C.M. Sergi, E. Symanski, E.M. Ward, V.H. Arrandale, K. Azuma, E. Brambila, G.M. Calaf, J.M. Fritz, S. Fukushima, J.M. Gaitens, T.K. Grimsrud, L. Guo, E. Lynge, A.P. Marinho-Reis, M.A. McDiarmid, D.R.S. Middleton, T.P. Ong, D.A. Polya, B. Quintanilla-Vega, G.K. Roberts, T. Santonen, R. Sauni, M.J. Silva, P. Wild, C.W. Zhang, Q. Zhang, Y Grosse, L. Benbrahim-Tallaa, A. de Conti, N.L. DeBono, F. El Ghissassi, F. Madia, B. Reisfeld, L.T. Stayner, E. Suonio, S. Viegas, R. Wedekind, S. Ahmadi, H. Mattock, W.M. Gwinn and M.K. Schubauer-Berigan. Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy. Lancet Oncol., vol. 23, no. 5, May, pp. 577-578, 2022. doi: 10.1016/S1470-2045(22)00219-4. DOI: https://doi.org/10.1016/S1470-2045(22)00219-4

Cobalt Institute. ‘” State of the cobalt market’ report”, Cobalt Institute, Guildford, UK, May, 2021. Available: https://www.cobaltinstitute.org/wp-content/uploads/2021/05/CobaltInstitute_Market_Report_2020_1.pdf, [Accessed July 20, 2023].

D.J. Paustenbach, B.E. Tvermoes, K.M. Unice, B.L. Finley and B.D. Kerger. A review of the health hazards posed by cobalt. Crit Rev Toxicol., vol. 43, no. 4, Apr., pp. 316-62, 2013. doi: 10.3109/10408444.2013.779633. DOI: https://doi.org/10.3109/10408444.2013.779633

IARC - International Agency for Research on Cancer, Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide. IARC Monogr Eval Carcinog Risks Hum., The International Agency for Research on Cancer, World Health Organization, vol. 86, 2006. (ebook).

Morrone, V. Bordignon, G.A. Barnabas, F. Dassoni, O. Latini, V. Padovese, F. Ensoli and A. Cristaudo. Clinical-epidemiological features of contact dermatitis in rural and urban communities in northern Ethiopia: correlation with environmental or occupational exposure. Int J Dermatol, vol. 53, Jan., pp. 975-980. 2014. doi: 10.1111/j.1365-4632.2012.05777.x. DOI: https://doi.org/10.1111/j.1365-4632.2012.05777.x

E.I. HamiltonI. The geobiochemistry of cobalt. Sci Total Environ., vol. 150, no. 1-3, June, pp. 7-39, 1994. doi: 10.1016/0048-9697(94)90126-0. DOI: https://doi.org/10.1016/0048-9697(94)90126-0

N. Arnich, V. Sirot, G. Rivière, J. Jean, L. Noël, T. Guérin and J.C. Leblanc. Dietary exposure to trace elements and health risk assessment in the 2nd French Total Diet Study. Food Chem Toxicol., vol. 50, no. 7, July, pp. 2432-49, 2012. doi: 10.1016/j.fct.2012.04.016. DOI: https://doi.org/10.1016/j.fct.2012.04.016

L. Noël, R. Chekri, S. Millour, C. Vastel, A. Kadar, V. Sirot, J.C. Leblanc and T. Guérin. Li, Cr, Mn, Co, Ni, Cu, Zn, Se and Mo levels in foodstuffs from the Second French TDS. Food Chem., vol. 132, no. 3, June, pp. 1502-1513, 2012. doi: 10.1016/j.foodchem.2011.12.009. DOI: https://doi.org/10.1016/j.foodchem.2011.12.009

C.R. Hamann, D. Hamann, C. Hamann, J.P. Thyssen and C. Lidén. The cost of nickel allergy: a global investigation of coin composition and nickel and cobalt release. Contact Dermatitis., vol. 68, no. 1, Jan., pp. 15-22, 2013. doi: 10.1111/cod.12008. DOI: https://doi.org/10.1111/cod.12008

W. Uter, M. Schmid, O. Schmidt, C. Bock and J. Wolter. Cobalt release from earrings and piercing jewellery - analytical results of a German survey. Contact Dermatitis., vol. 70, no. 6, June, pp. 369-75, 2014. doi: 10.1111/cod.12227. DOI: https://doi.org/10.1111/cod.12227

M.C. Bruzzoniti, O. Abollino, M. Pazzi, L. Rivoira, A. Giacomino and M. Vincenti. Chromium, nickel, and cobalt in cosmetic matrices: an integrated bioanalytical characterization through total content, bioaccessibility, and Cr(III)/Cr(VI) speciation. Anal Bioanal Chem., vol. 409, no. 29, Nov., pp. 6831-6841, 2017. doi: 10.1007/s00216-017-0644-8. DOI: https://doi.org/10.1007/s00216-017-0644-8

D.S. Lim, T.H. Roh, M.K. Kim, Y.C. Kwon, S.M. Choi, S.J. Kwack, K.B. Kim, S. Yoon, H.S. Kim and B.M. Lee. Non-cancer, cancer, and dermal sensitization risk assessment of heavy metals in cosmetics. J Toxicol Environ Health A., vol. 81, no. 11, March, pp. 432-452, 2018. doi: 10.1080/15287394.2018.1451191. DOI: https://doi.org/10.1080/15287394.2018.1451191

E. Pinto, M. Cruz, P. Ramos, A. Santos and A. Almeida. Metals transfer from tobacco to cigarette smoke: Evidences in smokers' lung tissue. J Hazard Mater., vol. 325, March, pp. 31-35, 2017. doi: 10.1016/j.jhazmat.2016.11.069. DOI: https://doi.org/10.1016/j.jhazmat.2016.11.069

IARC - International Agency for Research on Cancer. Chlorinated drinking-water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds. IARC Monogr Eval Carcinog Risks Hum. The International Agency for Research on Cancer, World Health Organization, vol. 52, 1991. (ebook)

J. Kettelarij, K. Midander, C. Lidén, M. Bottai and A. Julander. Neglected exposure route: cobalt on skin and its associations with urinary cobalt levels. Occup Environ Med., vol. 75, no. 11, Nov., pp. 837-842, 2018. doi: 10.1136/oemed-2018-105099. DOI: https://doi.org/10.1136/oemed-2018-105099

M. Bock, A. Schmidt, T. Bruckner and T.L. Diepgen. Occupational skin disease in the construction industry. Br J Dermatol., vol. 149, no. 6, Dec., pp. 1165-71, 2003. doi: 10.1111/j.1365-2133.2003.05748.x. DOI: https://doi.org/10.1111/j.1365-2133.2003.05748.x

FAO - Food and Agriculture Organization, “Human vitamin and mineral requirements”. Food and Agriculture Organisation of the United Nations, Rome, Italy. Report of a joint FAO/WHO expert consultation, Bangkok, Thailand, 2023. Available: https://www.fao.org/3/y2809e/y2809e.pdf. [Accessed July 14, 2023].

WHO – World Health Organization, “Cobalt and inorganic cobalt compounds”. World Health Organization Geneva, Switzerland. Available: https://apps.who.int/iris/bitstream/handle/10665/43426/9241530693_eng.pdf?sequence=1&isAllowed=yhttps://apps.who.int/iris/handle/10665/43426, [Accessed July 31, 2023].

D. Lison, “Cobalt”, in Handbook on the toxicology of metals, G.F. Nordberg, B.A. Fowler and M. Nordber, Eds., Academic Press, 4th ed, vol. II, 2015, pp 743–63. DOI: https://doi.org/10.1016/B978-0-444-59453-2.00034-2

J.R. González-Montaña, F. Escalera-Valente, A.J. Alonso, J.M. Lomillos, R. Robles and M.E. Alonso. Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update. Animals (Basel)., vol. 10, no. 10, Oct., pp. 1855, 2020. doi: 10.3390/ani10101855. DOI: https://doi.org/10.3390/ani10101855

J.P. Higgins, T.D. Tuttle and C.L. Higgins. Energy beverages: content and safety. Mayo Clin Proc., vol. 85, no. 11, Nov., pp. 1033-41, 2010. doi: 10.4065/mcp.2010.0381. DOI: https://doi.org/10.4065/mcp.2010.0381

L.O. Simonsen, H. Harbak and P. Bennekou. Cobalt metabolism and toxicology--a brief update. Sci Total Environ., vol. 432, Aug., pp. 210-5, 2012. doi: 10.1016/j.scitotenv.2012.06.009. DOI: https://doi.org/10.1016/j.scitotenv.2012.06.009

T. Pongcharoensuk and S. Thaiwat. Systemic pigmented contact dermatitis to cobalt following ingestion of cobalamin supplement. Clin Case Rep., vol. 9, no. 5, Apr., pp. e04103, 2021. doi: 10.1002/ccr3.4103. DOI: https://doi.org/10.1002/ccr3.4103

J. Mohmand, S.A. Eqani, M. Fasola, A. Alamdar, I. Mustafa, N. Ali, L. Liu, S. Peng and H. Shen. Human exposure to toxic metals via contaminated dust: Bio-accumulation trends and their potential risk estimation. Chemosphere., vol. 132, Aug., pp. 142-51, 2015. doi: 10.1016/j.chemosphere.2015.03.004. DOI: https://doi.org/10.1016/j.chemosphere.2015.03.004

J. Iqbal, S.A. Tirmizi and M.H. Shah. Non-carcinogenic health risk assessment and source apportionment of selected metals in source freshwater Khanpur Lake, Pakistan. Bull Environ Contam Toxicol., vol. 88, no. 2, Feb., pp. 177-81, 2012. doi: 10.1007/s00128-011-0480-z. DOI: https://doi.org/10.1007/s00128-011-0480-z

S. Sharma, A.K. Nagpal and I. Kaur. Heavy metal contamination in soil, food crops and associated health risks for residents of Ropar wetland, Punjab, India and its environs. Food Chem., vol. 255, Feb., pp. 15–22, 2018. doi: 10.1016/j.foodchem.2018.02.037. DOI: https://doi.org/10.1016/j.foodchem.2018.02.037

J. Cheng, X. Zhang, S. Ren, T. Wang and Z. Tang. Metals in wild fish from Gaotang Lake in the area of coal mining, China: assessment of the risk to human health. Environ Sci Pollut Res Int., vol. 26, no. 23, Aug., pp. 23754-23762, 2019. doi: 10.1007/s11356-019-05732-8. DOI: https://doi.org/10.1007/s11356-019-05732-8

K. Cheyns, C. Banza Lubaba Nkulu, L.K. Ngombe, J.N. Asosa, V. Haufroid, T. De Putter, T. Nawrot, C.M. Kimpanga, O.L. Numbi, B.K. Ilunga, B. Nemery and E. Smolders. Pathways of human exposure to cobalt in Katanga, a mining area of the D.R. Congo. Sci Total Environ., vol. 490, Aug., pp. 313-21, 2014. doi: 10.1016/j.scitotenv.2014.05.014. DOI: https://doi.org/10.1016/j.scitotenv.2014.05.014

A.P. Marinho-Reis, C. Costa, F. Rocha, M. Cave, J. Wragg, T. Valente, A. Sequeira-Braga and Y. Noack. Biogeochemistry of Household Dust Samples Collected from Private Homes of a Portuguese Industrial City. Geosciences, vol. 10, no. 10, Oct., pp. 392, 2020. doi: 10.3390/geosciences10100392 DOI: https://doi.org/10.3390/geosciences10100392

C.M. Bastos, F. Rocha, C. Patinha and P. Marinho-Reis. Bioaccessibility by perspiration uptake of minerals from two different sulfurous peloids. Environ Geochem Health, vol. 45, June, pp. 6621–6641, 2023. doi: 10.1007/s10653-023-01639-z. DOI: https://doi.org/10.1007/s10653-023-01639-z

V.M. Ngole-Jeme and P. Fantke. Ecological and human health risks associated with abandoned gold mine tailings contaminated soil. PLoS One, vol. 12, no. 2, Feb., pp. e0172517, 2017. doi: 10.1371/journal.pone.0172517. DOI: https://doi.org/10.1371/journal.pone.0172517

J. Lützner, K.P. Günther, A. Postler and M. Morlock. Metal Ion Release after Hip and Knee Arthroplasty - Causes, Biological Effects and Diagnostics. Z Orthop Unfall., vol. 158, no. 4, Aug., pp. 369-382, 2020. doi: 10.1055/a-0929-8121. DOI: https://doi.org/10.1055/a-0929-8121

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2024-03-19 — Updated on 2024-03-20

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